Yes, both are safe neighborhoods. That being said, you must always be aware of your surroundings and your belongings. Club Quarters is literally one block from Wall Street. Here is the hotel website http://www.clubquarters.com/loc_nyWallstreet.php Four Points Soho is within walking distance to Little Italy and Chinatown. Greenwich Village is probably around a 15 block walk (you could also take a cab or subway). The website for Four Points is: http://www.starwoodhotels.com/fourpoints/property/overview/index.html?propertyID=1537 All-in-all, plenty to do in both neighborhoods. More restaurants in Soho, for sure. Honestly, you can't go wrong with either one of these properties. The rooms are immaculate and the service is very good. Have a great visit!