If you want to do the touristy thing, visit the honky tonks, maybe a show at the Ryman or Bridgestone Arena, enjoy some adult beverages - downtown is the place to be, but it's popular so the prices are high. The Vanderbilt area is fine and is a great second choice for Nashville visitors. Prices will generally be cheaper at the Vandy/West End area, parking will cost $20ish/nt instead of $30ish/nt - most of the hotels have shuttles that will take you to "lower Broad" which is the main tourist district, which is maybe 2 miles away - if you don't want to wait on the shuttle, Uber is easily available if you download the app, or you can even take the city bus.
I rarely drink, and when I do, generally no more than two drinks, so the convenience of being able to walk back to the hotel is not a big deal to me. I am, however, cost conscious (hey, I use Price.line!), so usually when I go to Nashville I stay out in the suburbs (my friends live there anyway) for a lower rate and drive in and park (for free) at Nissan Stadium when I visit downtown. However, as a first timer, I would recommend staying downtown, alternatively at the Vandy/West End area.